ABSTRACT
Since 2020, the precedence of COVID-19 and its variants has made a significant impact on the global fashion industry and instigated a fundamental change in consumer purchasing behaviour. A series of lockdowns, travel restrictions, social distancing has forced consumers to rely on and adapt to online shopping methods, causing major branding retail companies to innovate new online based consumer interaction systems. Moreover, work from home has significantly cut down sales in formal wear, while outing restrictions and social distancing has further cut down demand for fast and luxury fashion. Consumer needs and preferences in turn have reoriented towards home comfort and athleisure wear, as well as essential wearables. However, the current online shopping platforms do not provide a way for consumers to specify their own needs and preferences which leads to dissatisfaction for consumers, uncertainty in consumer purchases resulting in high inventory risk for branding retailers, as well as suppliers. This paper introduces how consumer's needs and preferences can be linked with product performance on e-shopping platforms with the novel consumer interactive system "Fashion Big Data (FBD) API plugins". It will describe how the FBD API plugins can enable consumers to set their own needs and preferences;compare consumers' needs and preferences with certified product performance;and provide respective smart personalized product recommendations. The paper will demonstrate real business case examples with hand feel, skin feel and thermal wear comfort FBD API plugins from the EU Horizon 2020, Fashion Big Data Model (FBD B_MODEL) project. This will be followed by FBD B_MODEL business case partner and consumer feedback. © Textile Bioengineering and Informatics Symposium Proceedings 2022 - 15th Textile Bioengineering and Informatics Symposium, TBIS 2022.
ABSTRACT
The COVID-19 pandemic has catalysed the change in fashion consumer demand. With more apparel consumers turning to online shopping, brand owners, retailers, and suppliers in the textile industry supply chain are facing new challenges in transitioning from the traditional offline business model to the new online business model. This paper first discusses the behavioural changes of fashion consumers, the supply chain participants, and the policymakers, and identifies the pain points of the industry. To address these pain points, the FBD digital fashion business model was then proposed, and the C2B2B ICT platform was developed to enable fashion brandings, retailers, and manufacturers to adopt the new business model. The architecture of the digital platform is explained. Finally, the paper introduces how the retailer, garment manufacturer, fabric manufacturer, yarn manufacturer and fibre manufacturer can build up their digital business models by using the FBD C2B2B platform with real case studies. © Textile Bioengineering and Informatics Symposium Proceedings 2022 - 15th Textile Bioengineering and Informatics Symposium, TBIS 2022.
ABSTRACT
Objective To explore the application and safety of apheresis technology in collection of Coronavirus Disease 2019 (COVID-19) convalescent plasma (CP), and to analyze the quality characteristics of the plasma. Methods The general data of COVID-19 convalescent plasma (CP) donors, including gender, age, date of discharge or release from medical isolation, were collected based on informed consent. After physical examination, the CP was collected by apheresis technology with plasma separator, inactivated with methylene blue, and determined for severe acute respiratory symptom Coronavirus 2 (SARS-CoV-2) nucleic acid and specific antibody (RBD-IgG) against SARS-CoV-2. Results The collection process went well, and no serious adverse events related to plasma collection were reported during or after the collection. The average age of COVID-19 CP donors was 38 years (n = 933). The distributions of blood groups A, B, AB and 0 in RhD (+) COVID-19 CP were 33. 4%, 29. 2%, 10% and 27. 2% respectively. The plasma donation date was 18 d from the discharge date in average. All the test results of SARS-CoV-2 nucleic acid in CP were negative, while the proportion of plasma samples at SARS-CoV-2 antibody titer of more than 1: 160 was 92. 60%. Conclusion Apheresis technology was safe and reliable. The COVID-19 CP contained high titer antibody. Large-scale collection and preparation of inactivated plasma against SARS-CoV-2 played an important role in the treatment of COVID-19.
ABSTRACT
Objective: To compare the correlation between the results of SARS-CoV-2 neutralizing antibody colloidal gold test cards prepared by two different principles and the SARS-CoV-2 pseudovirus neutralization experiment, and to evaluate the feasibility of the neutralizing antibody colloidal gold test card for the SARS-CoV-2 neutralizing antibody detection in different populations. Methods: Two kinds of SARS-CoV-2 neutralizing antibody colloidal gold test cards using double antigen sandwich method (manufacturer A) and competitive blocking method (manufacturers B) were used to detect the samples with SARS-CoV-2 neutralizing antibody titers. Detection sensitivity and the correlation between the two methods and the neutralization experiment were compared. The intravenous human immunoglobulin and specific immunoglobulin prepared before the outbreak of COVID-19 epidemic were detected to investigate the specificity of the eligible test card. In order to determine whether there is a hook effect, individual immunized plasma samples of high ELISA titers were tested with series of dilutions and original dilution. Single post-immunized plasma samples were detected with different ELISA titers, the positive rates were determined and the color changes were observed. Single post-immunized plasma samples were screened in the low-dilution area of ELISA according to chromaticity of 120NT50 and 300NT50 on the colorimetric card to prepare pooled plasma. The results were compared with the currently used indirect ELISA method. Results: The detection limits of manufacturers A and B for the first-generation NIBSC international standard 20/136 (anti-SARS-CoV-2 human immunoglobulin international standard) were 0.612 5 and 5 IU•mL-1, respectively. The results of different titers of pooled plasma (both of post-immunization with SARS-CoV-2 vaccine and COVID-19 convalescence plasma) have a good correlation with the neutralizing antibody titer. The post-immunization plasma with high ELISA dilutions (above 10 000) did not show hook effect. The positive rate of individual plasma of different ELISA dilution levels reached 100% when the dilution was above 160, and the uniformity of the chromaticity was higher when the dilution level was above 640. The overall chromaticity became darker as the ELISA dilution increased. The chromaticities of Ppool 120NT50 and Ppool 300NT50 screened according to the colorimetric chart were close to the neutralizing antibody titers. Conclusion: The correlation between the results of the manufacturer A neutralizing antibody test card using the dual antigen sandwich method to detect SARS-CoV-2 neutralizing antibody in convalescent plasma and post-immunization plasma and the titer of the pseudovirus neutralization experiment is better than that of the manufacturer B product using the competitive inhibition method and indirect ELISA. And the color brightness of the detection line is positively correlated with the level of neutralizing antibody, which can be used for preliminary screening of neutralizing antibody in different populations.
ABSTRACT
Objective To establish a SARS-CoV-2 antibody sample panel and apply to the quality evaluation of test cassettes for colloidal gold lateral flow assay. Methods SARS-CoV-2 antibody sample panel was established with the convalescent plasma samples from patients with Corona Virus Disease 2019 (COVID-19) and optimized. Suggestions for modification were put forward on the sample panels from three manufacturers (S, L and H), and the test cassettes after modification were analyzed and compared. Results The accuracy, sensitivity, specificity and Youden index of cassette from manufacturer S were 92. 54%, 90. 78%, 100% and 0. 908 respectively, while the positive test region was light in color and not easy to be recognized. However, after modification, the accuracy, sensitivity, specificity and Youden index were 95. 35%, 98. 91%, 97. 19% and 0. 943 respectively, while the color of positive test region was developed obviously and easy to be recognized. The sensitivity of cassette from manufacturer L was only 14. 28% before modification, while the positive test region was unobvious in color, indicating a high missed detection rate. However, after modification, the sensitivity for IgM was 98. 63% , while the color of positive test region was developed obviously and rapidly. The sensitivity, specificity, accuracy and Youden index were 98. 08%, 100. 00%, 98. 90% and 0. 981 for IgG, while were 84. 50%, 86. 49%, 85. 71% and 0. 710 for IgM, respectively. Conclusion The developed sample panel may be used for the quality evaluation of SARS-CoV-2 antiobdy detection reagents. © 2021 Changchun Institute of Biological Products. All rights reserved.